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Hyperhomocysteinemia in epileptic patients on new antiepileptic drugs
Epilepsia, 09/24/09
Belcastro V et al. – Oxcarbazepine and topiramate might cause hyper–tHcy, most likely because of the capacity of these agents to induce the hepatic enzymes. Because literature data suggest that hyper–tHcy may contribute to the development of cerebrovascular diseases and brain atrophy, a supplement of folate can be considered in these patients to normalize plasma tHcy.
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