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Identification and Functional Characterization of Phosphorylation Sites on GTP Cyclohydrolase I
Arteriosclerosis, Thrombosis, and Vascular Biology, 09/22/09
Du J et al. – The data suggest GCH–1 activity is regulated either positively by phosphorylation S51, S72, T85, T91, T103, and S130, or negatively at T231. Such information might be useful in designing new therapies aiming at improving BH4 bioavailability.
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