Heart Disease Journals

Cardiology

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Orbe J et al. – Thrombin induces MMP–10 through a PAR–1–dependent mechanism mediated by ERK1/2, JNK, and AP–1 activation. Endothelial MMP–10 upregulation could be regarded as a new proinflammatory effect of thrombin whose pathological consequences in thrombin–related disorders and plaque stability deserve further investigation.


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