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Inhibition of Prolyl Hydroxylase Domain-Containing Protein Suppressed Lipopolysaccharide-Induced TNF-alpha Expression
Arteriosclerosis, Thrombosis, and Vascular Biology, 09/22/09
Takeda K et al. – HD inhibition by DMOG or RNA interference inhibited LPS–induced TNF–alpha upregulation in macrophages possibly through NF–kB inhibition, which is independent of HIF–1–alpha accumulation. This study suggests that PHDs are positive regulators of LPS–induced inflammatory process, and therefore inhibition of PHD may be a novel strategy for the treatment of inflammatory diseases.
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