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See Latest ArticlesUltrastructural and Functional Remodeling of the Coupling Between Ca2+ Influx and Sarcoplasmic Reticulum Ca2+ Release in Right Atrial Myocytes From Experimental Persistent Atrial Fibrillation
Circulation Research, 09/22/09
Lenaerts I et al. – In persistent AF, reduced SR Ca2+ release despite preserved SR Ca2+ content is a major factor in contractile dysfunction. Fewer Ca2+ channel–RyR couplings and reduced efficiency of the coupling at subsarcolemmal sites, possibly related to increased Na+/Ca2+ exchanger, underlie the reduction in Ca2+ release.
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