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The Role of Nicotinamide Adenine Dinucleotide Phosphate Oxidase in the Pathogenesis of Hypertension
High Blood Pressure & Cardiovascular Prevention, 09/21/09

Loffredo L et al. – Nicotinamide adenine dinucleotide phosphate (NADPH) activation is considered as the major reactive oxygen species source and could be implicated in the pathogenesis of hypertension. A large body of evidences coming from animal studies have generally supported the hypothesis that high blood pressure is associated with increased oxidative stress and with NADPH activation; conversely, human studies provided divergent results. This review analyses the data reported so far to determine the role of NADPH oxidase in the pathogenesis of hypertension.

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