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See Latest ArticlesGene Transfer of Inducible Nitric Oxide Synthase Affords Cardioprotection by Upregulating Heme Oxygenase-1 Via a Nuclear Factor-kB–Dependent Pathway
Circulation, 09/17/09
Li Q et al. – This study demonstrates for the first time the existence of a close functional coupling between cardiac iNOS and cardiac HO–1: iNOS upregulates HO–1 by augmenting nuclear factor–kB binding to the region of the HO–1 gene promoter from –468 to –459 bp, and HO–1 then mediates the cardioprotective effects of iNOS. These results also reveal an important role of nuclear factor–kB in both basal and iNOS–induced expression of cardiac HO–1. Collectively, the present findings significantly expand the understanding of the regulation of cardiac HO–1 and of the mechanism whereby iNOS exerts its cardioprotective actions.
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