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Replicative senescence of vascular smooth muscle cells enhances the calcification through initiating the osteoblastic transition
Heart And Circulatory Physiology, 09/15/09
Nakano–Kurimoto R et al. – The findings strongly suggest an important role of senescent VSMCs in the pathophysiology of senescence–associated medial calcification, and the inhibition of osteoblastic transition could be a new therapeutic approach for the prevention of senescence–associated medial calcification.
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