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See Latest ArticlesCardiac Na+ Current Regulation by Pyridine Nucleotides
Circulation Research, 09/15/09
Liu M et al. – The results show that Nav1.5 is regulated by pyridine nucleotides, suggesting a link between metabolism and INa. This effect required protein kinase C activation and was mediated by oxidative stress. NAD+ could prevent this effect by activating PKA. Mutations of GPD1–L may downregulate Nav1.5 by altering the oxidized to reduced NAD(H) balance.
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