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See Latest ArticlesMetabolic syndrome is associated with increased arterial stiffness and biomarkers of subclinical atherosclerosis in patients with systemic lupus erythematosus
Journal of Rheumatology, 09/11/09
Sabio JM et al. – MetS may contribute to the development of accelerated atherosclerosis in SLE.
Methods- 128 patients with SLE
- SLE patients with MetS had higher aortic PWV (9.8 ± 2.4 vs 8.5 ± 1.7 m/s) and increased biomarkers of subclinical atherosclerosis such as CRP, IL-6, C3, uric acid, homocysteine, fibrinogen and D-dimer, compared to those without MetS
- HOMA index and insulin and HbA1c levels were also higher in this group
- No differences were found in variables related to lupus activity (ESR, C4, SLEDAI, IL-8, IL-10, and treatment for SLE)
- In the multivariate model, increased PWV was associated with age, male sex, MetS, duration of SLE, and CRP
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