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See Latest ArticlesCardiac transgenic matrix metalloproteinase-2 expression induces myxomatous valve degeneration: a potential model of mitral valve prolapse disease
Cardiovascular Pathology, 09/10/09
Mahimkar R et al. – This report demonstrates that increased activity of a single enzyme, MMP–2, within a transgenic context reproduces many of the features of the human MVP syndrome. The cardiac–specific MMP–2 transgenic mouse potentially provides a unique experimental platform for the evaluation of nonsurgical therapies based on the underlying pathophysiology of this disease.
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Vascular Endothelial Growth Factor–Secreting Mast Cells and Myofibroblasts. A Novel Self-Perpetuating Angiogenic Pathway in Aortic Valve Stenosis
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