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See Latest ArticlesVascular Responses to Hypoxia and Ischemia
Arteriosclerosis, Thrombosis, and Vascular Biology, 09/04/09
Semenza GL – Blood vessels function as conduits for the delivery of O2 and nutrients. Hypoxia–inducible factor 1 (HIF–1) mediates adaptive transcriptional responses to hypoxia/ischemia that include expression of angiogenic cytokines/growth factors by hypoxic cells and expression of cognate receptors for these ligands by vascular cells and their progenitors. Impairment of HIF–1–dependent responses to hypoxia is a major factor contributing to the impaired vascular responses to ischemia that are associated with aging and diabetes.
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