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A novel SCN5A mutation V1340I in Brugada syndrome augmenting arrhythmias during febrile illness
Heart Rhythm, 09/02/09
Samani K et al. – The study supports the concept that febrile illness predisposes individuals who carry a loss of function SCN5A mutation, such as V1340I, to fever–induced ventricular arrhythmias in BrS by significantly reducing the sodium currents in the hyperthermic state.
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