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See Latest ArticlesNitric Oxide, Cytochrome C Oxidase, and the Cellular Response to Hypoxia
Arteriosclerosis, Thrombosis, and Vascular Biology, 08/31/09
Taylor CT et al. – At lower oxygen concentrations, when CcO is predominantly reduced, NO is not consumed and accumulates in the microenvironment, with implications for both the respiratory rate of cells and the local vascular tone. Changes in the availability of intracellular oxygen and in the generation of reactive oxygen species that accompany these interactions result in cell signaling and in regulation of oxygen–sensitive pathways that ultimately determine the nature of the cellular response to hypoxia.
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