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See Latest ArticlesS100A4 and Bone Morphogenetic Protein-2 Codependently Induce Vascular Smooth Muscle Cell Migration via Phospho–Extracellular Signal-Regulated Kinase and Chloride Intracellular Channel 4
Circulation Research, 08/31/09
Spiekerkoetter E et al. – The studies demonstrate how a single ligand (BMP–2 or S100A4/Mts1) can recruit multiple cell surface receptors to relay signals that coordinate events culminating in a functional response, ie, cell motility. The authors speculate that this carefully controlled process limits signals from multiple ligands, but could be subverted in disease.
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