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Nanda A et al. – Neoadjuvant HT use is significantly associated with an increased risk of all-cause mortality among men with a hx of CAD-induced CHF or MI, but not among men with no comorbidity or a single CAD risk factor.
Methods- 5077 men with localized or locally advanced prostate cancer were consecutively treated with or without a median of 4 mos of neoadjuvant HT followed by RT
- Neoadjuvant HT use was not associated with an increased risk of all-cause mortality in men with no co-morbidity or a single CAD risk factor after a median f/u of 5 and 4.4 y, respectively
- For men with CAD-induced CHF or MI, after a median f/u of 5.1 y, neoadjuvant HT use was significantly associated with an increased risk of all-cause mortality
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