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See Latest ArticlesTranscriptional and posttranscriptional regulators of biglycan in cardiac fibroblasts
Basic Research in Cardiology , 08/25/09
Tiede K et al. – The current results suggest that in cardiac fibroblasts, biglycan is induced by a variety of stimuli including serum, thrombin and growth factors such as PDGF–BB and TGF-beta-1. This response is counteracted by NO and enhanced by TNF-alpha. Interestingly, both up– and downregulation were associated with posttranslational increase of GAG chain length.
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