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Park JY et al. – The current findings indicate that p53 promotes aerobic metabolism and exercise capacity by using different mitochondrial genes and mechanisms in a tissue–specific manner.


Exclusive Author Commentary
Paul M. Hwang, 08/24/09

Although there may be many different reasons for the observed inverse relationship between cardiorespiratory fitness and cancer, the above finding involving the important tumor suppressor gene p53 may be one additional mechanism to consider.

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