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Obesity paradox in a cohort of 4880 consecutive patients undergoing percutaneous coronary intervention
European Heart Journal, 08/21/09
Hastie CE et al. – Among pts undergoing percutaneous coronary intervention (PCI) for coronary artery disease, increased body mass index (BMI) was associated with improved 5-yr survival. Among pts with established coronary disease, adverse effects of excess adipose tissue may be offset by beneficial vasoactive properties.
Methods- Study of BMI impact on long-term all-cause mortality in pts after first-time elective PCI
- Scottish Coronary Revascularisation Register for cohort study of all elective PCI pts in Scotland April 1997-March 2006 inclusive
- Exclusion of pts with previous revascularization
- Within 5 years of 4880 procedures, 219 deaths
- Reduced risk of dying for pts with BMI ≥27.5 and <30 vs normal weight pts
- No attenuation of association after adjustment for potential confounders: age, hypertension, diabetes, and left ventricular function
- No statistically significant interactions
- Results unaltered by restricting analysis to events >30-day follow-up
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