Heart Disease Journals

Cardiology

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Kandasamy AD et al. – GSK–3–beta may be a target of MMP–2 and its cleavage by MMP–2 enhances its kinase activity. MMP–2 may cleave off the N–terminal of GSK–3–beta where the inhibitory phosphorylation of serine–9 occurs. MMP–2–mediated augmentation of GSK–3–beta kinase activity may contribute to cardiac injury resulting from enhanced oxidative stress.


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