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PPAR-gamma agonist rosiglitazone reverses increased cerebral venous hydraulic conductivity during hypertension
Heart And Circulatory Physiology, 08/11/09
Roberts TJM et al. – The results demonstrate that rosiglitazoine was effective at reversing changes in venous permeability that occurred during chronic hypertension, an effect that does not appear to be related to its antioxidant properties. The findings suggest that PPAR–gamma may be a key regulator of BBB permeability and a potential therapeutic target during hypertension.
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