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Hodson L et al. - In this small–scale study, the DASH diet lowered BP independently of peripheral mechanisms.

Exclusive Author Commentary
KN Frayn, 08/10/09

The DASH diet has been shown to be an effective non-pharmacological means of reducing blood pressure. But the mechanisms by which it does this are not clear. In this study, we tested whether lowering of blood pressure by the DASH diet involved changes in peripheral circulatory control, as measured by endothelial function (in the brachial artery) and blood flow regulation in subcutaneous adipose tissue. We confirmed good blood pressure lowering with DASH diet but found no effect on these 'peripheral' measures, impying cardiac/central mechanisms. The study was small and might provide pilot data for larger studies. A novel observation was that blood levels of apolipoprotein-B (a cardiovascular risk marker) as well as LDL-cholesterol (already known) were improved with DASH diet.

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