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Resveratrol reverses ET-1-evoked mitogenic effects in human coronary arterial cells by activating the kinase-G to inhibit ERK-enzymes
International Journal of Cardiology, 08/10/09
El–Mowafy AM et al. – The results demonstrate a novel signaling pathway for RSVL that leads from activation of the pGC/kinase–G system to inhibition of ERK1/2 and their downstream nuclear targets. This pathway functions to counteract the atherogenic signaling induced by vascular mitogens.
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