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See Latest ArticlesExercise function of children with congenital aortic stenosis following aortic valvuloplasty during early infancy
Congenital Heart Disease, 08/03/09
Kipps AK et al. – Although exercise function is preserved in most pts with history of treated neonatal aortic stenosis (AS), a subset have markedly reduced peak oxygen consumption (VO2) due to an inability to increase stroke volume.
Methods- Study to characterize exercise function of pts treated with balloon aortic valvuloplasty at age ≤6 mo
- Identification of factors associated with exercise dysfunction
- Prospective study of pts age >6 yrs with history of neonatal AS
- Exercise testing for 30 pts (median age 13.1 yrs)
- Balloon aortic valvuloplasty at median age 12 days
- On exercise testing, median maximum Doppler AS gradient: 34 mm Hg (0-70 mm Hg)
- Moderate or severe aortic regurgitation for 11 pts
- All pts asymptomatic
- Overall, peak VO2 below normal (87 ± 18% predicted); severely depressed (≤70% predicted) in 7 pts (23%)
- Peak O2 pulse well preserved overall (97 ± 22% predicted), 11 pts had O2 pulse <85% predicted, including all pts with VO2 ≤70% predicted
- Peak heart rate below normal overall (91 ± 7% predicted); rare (1 pt) severe chronotropic dysfunction (≤70% predicted)
- Age at testing correlated inversely with peak VO2
- No other demographic, historical, or echocardiographic variables associated with peak VO2
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