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Chronic hypoxia inhibits MMP-2 activation and cellular invasion in human cardiac myofibroblasts
Journal of Molecular and Cellular Cardiology, 08/04/09
Riches K et al. – Hypoxia reduces MMP–2 activation and subsequent invasion of human cardiac myofibroblasts by reducing membrane expression of MT1–MMP and may delay healing after MI. Regulation of these MMPs remains an attractive target for therapeutic intervention.
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