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See Latest ArticlesEfficacy of genistein aglycone on some cardiovascular risk factors and homocysteine levels: A follow-up study
Nutrition, Metabolism & Cardiovascular Diseases, 07/30/09
Marini H et al. – After 3 yrs of treatment, genistein aglycone plus calcium, vitamin D3 and a healthy diet showed positive effects on some cardiovascular risk factors and homocysteine levels in a cohort of postmenopausal women with low bone mass.
Methods- Study of the effects of genistein aglycone on some cardiovascular risk factors and homocysteine levels after 3 yrs of continued therapy in cohort of osteopenic, postmenopausal women
- Parent study: randomized, double-blind, placebo-controlled trial involving 389 postmenopausal women with low bone mass for 24 mo
- Subcohort analysis of 138 pts who continued therapy for 1 additional yr
- Administration of 54 mg/day of genistein aglycone (71 pts) or placebo (67 pts)
- Both arms received calcium and vitamin D3 in therapeutic doses
- Dietary instructions for isocaloric fat-restricted diet 4 wks before randomization procedures and during follow-up study
- Measurement of blood lipid profiles, fasting glucose and insulin, insulin resistance (HOMA-IR), fibrinogen, osteoprotegerin (OPG) and homocysteine at baseline and after 24 and 36 mo of treatment
- Compared with placebo, genistein significantly decreased fasting glucose and insulin, HOMA-IR, fibrinogen and homocysteine after 24 mo and 36 mo of treatment
- Isoflavone administration did not affect high-density lipoprotein cholesterol and triglycerides
- Serum OPG higher in genistein pts
- No differences in adverse events or discomfort between groups
- Results on routine biochemical, liver function, and hematologic testing did not change over time in placebo or genistein group
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