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Established neointimal hyperplasia in vein grafts expands via TGF-beta mediated progressive fibrosis
Heart And Circulatory Physiology, 07/23/09
Jiang Z et al. – Enhanced signaling via TGF–beta/CTGF coupled with reduced MMP activities promotes progressive fibrotic NIH expansion. Modulation of late TGF–beta/CTGF signaling may offer a novel therapeutic strategy to improve the long–term VG durability.
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