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The prognostic importance of modifiable risk factors after heart transplantation
American Heart Journal, 07/23/09

Arora S et al. – Smoking is a risk factor for all-cause and cardiac mortality, but elevated total cholesterol is a risk factor only in absence of statin therapy started at the time of heart transplantation (HTx).

Methods

Study of prognostic importance of smoking, obesity, hyperglycemia and hyperlipidemia 1 yr after HTx for all-cause and cardiac mortality
Evaluation of 381 pts at first annual visit post-HTx
Review of data for modifiable risk factors and other clinical variables
Median follow-up: 7.4 yrs

Results

In total, there were 122 (32%) deaths and smoking and elevated total cholesterol were independent risk factors for all-cause mortality
Significantly higher incidence of cardiac death for smokers and pts with elevated total cholesterol
Elevated body mass index and hemoglobin A1c did not affect prognosis
Elevated total cholesterol not a risk factor in protocol of statin therapy started at time of HTx

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