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Interatrial mechanical dyssynchrony worsened atrial mechanical function in sinus node disease with or without paroxysmal atrial fibrillation
Journal of Cardiovascular Electrophysiology, 07/17/09
Wang M et al. – Sinus node disease (SND) pts with paroxysmal atrial fibrillation (AF) had reduced regional and global active midleft atrial (LA) mechanical contraction and increased interatrial dyssychrony vs pts without AF. These findings suggest that abnormal atrial electromechanical properties are associated with AF in SND pts.
Methods- Study of prevalence and impact of atrial mechanical dyssynchrony on atrial function in SND pts with/without paroxysmal AF
- Echocardiographic examination with tissue Doppler imaging in 30 SND pts with (11) or without (19) paroxysmal AF who received dual-chamber pacemakers
- Tissue Doppler indexes: atrial contraction velocities (Va) and timing events (Ta) measured at LA and right atrial (RA) wall
- Intraatrial synchronicity defined by standard deviation and maximum time delay of Ta among 6 segments of LA (septal/lateral/inferior/anterior/posterior/anterospetal)
- Interatrial synchronicity defined by time delay between Ta from RA and LA free wall
- No differences in age, P-wave duration, left ventricular ejection fraction, LA volume, and ejection fraction between with/without AF
- Pts with paroxysmal AF had lower mitral inflow A velocity, LA active empting fraction, mean Va of LA, and greater interatrial synchronicity vs pts without AF
- Lower mitral inflow A velocity and prolonged interatrial dyssynchrony: independent predictors for presence of AF in SND pts
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