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Cardiac peroxisome proliferator-activated receptor-alpha activation causes increased fatty acid oxidation, reducing efficiency and post-ischaemic functional loss
Cardiovascular Research, 07/20/09
Hafstad AD et al. – This study for the first time observed that in vivo administration of a synthetic PPAR–alpha ligand elevated FA oxidation, an effect that was also associated with decreased cardiac efficiency and reduced post–ischaemic functional recovery.
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