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See Latest ArticlesEndothelin-I and angiotensin II inhibit arterial voltage-gated K+ channels through different protein kinase C isoenzymes
Cardiovascular Research, 07/17/09
Rainbow RD et al. – ET–1 inhibits Kv channels of mesenteric ASM through activation of PKC–alpha, while AngII does so through PKC–epsilon. This implies that ET–1 and AngII target Kv channels of ASM through different pathways of PKC–interacting proteins, so each vasoconstrictor enables its distinct PKC isoenzyme to interact functionally with the Kv channel.
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