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CD36-mediated cholesterol efflux is associated with PPAR-gamma activation via a MAPK-dependent COX-2 pathway in macrophages
Cardiovascular Research, 07/16/09
Bujold K et al. - The findings suggest a central role for the prostanoid 15d-PGJ2 in PPAR-gamma activation and the upregulation of the ABC transporter pathway in response to CD36 activation by synthetic GHRPs analogues. The resulting enhanced cholesterol efflux might explain, at least in part, the atheroprotective effect of selective CD36 ligands.
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