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Reduction of Repolarization Reserve Unmasks the Pro-arrhythmic Role of Endogenous Late Sodium Current in the Heart
Heart And Circulatory Physiology, 07/22/09
Wu L et al. – Endogenous, physiological late INa contributes to arrhythmogenesis in hearts with reduced repolarization reserve. Inhibition of this current partially reverses MAPD prolongation and abolishes arrhythmic activity caused by IK inhibitors.
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