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Siebenhofer A et al. - Drugs such as orlistat, sibutramine or rimonabant are sometimes suggested to assist in weight reduction and blood pressure reduction. Orlistat and sibutramine have been shown to modestly reduce weight. Orlistat also reduced blood pressure but sibutramine increased blood pressure. No study investigating rimonabant was found. No evidence is available for effects of any of these drugs on death or morbidity. The most frequent side effects were gastrointestinal for orlistat and dry mouth, constipation and headache for sibutramine.

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