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See Latest ArticlesTrends in cardiovascular disease risk factors in individuals with and without diabetes mellitus in the Framingham Heart Study
Circulation, 07/08/09
Preis SR et al. – Compared with pts without diabetes mellitus, diabetic pts had a greater increase in body mass index, greater decrease in low-density lipoprotein cholesterol, and similar magnitude of decline in systolic blood pressure. Pts with diabetes mellitus have not experienced the necessary declines in CVD risk factors to overcome an increased risk of cardiovascular disease (CVD). Further efforts are needed to aggressively control CVD risk factors among pts with diabetes mellitus.
Methods- Study of CVD risk factor level changes among pts with and without type 2 diabetes mellitus from 1970-2005 in the Framingham Heart Study
- Assessment of 4195 pts (3990 without diabetes; 205 with diabetes) age 50 yrs and 3495 (3178 without diabetes; 317 with diabetes) age 60 yrs
- Contemporaneous CVD risk factor levels measured
- Linear regression models to assess interaction between diabetes status and calendar year on CVD risk factor levels
- Among 50-yr-olds without diabetes mellitus, an increase in body mass index of 0.39 kg/m2 per 10 yrs vs an increase of 2.52 kg/m2 for pts with diabetes
- For low-density lipoprotein cholesterol, mean decrease was -7.43 mg/dL per decade (nondiabetes) vs -15.5 mg/dL for diabetes
- For systolic blood pressure, mean decrease was -3.35 mm Hg per decade (nondiabetes) and -3.50 mm Hg for diabetes
- Direction of trends for pts with diabetes relative to pts without diabetes was similar for 60-year-olds
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