Cardiology

Your Article Summary

See Latest Articles

The adverse long-term impact of renal impairment in patients undergoing percutaneous coronary intervention in the drug-eluting stent era
Circulation: Cardiovascular Interventions, 07/02/09

Appleby CE et al. – In a large registry of "all comers" for percutaneous coronary intervention, chronic kidney disease (CKD) was an independent predictor of adverse late outcomes. Drug-eluting stent (DES) use may be associated with improved long-term outcomes in this high-risk cohort, pending further prospective studies.

• Observational study of long-term impact of CKD on pts undergoing percutaneous coronary intervention at a tertiary cardiac referral center
• Review of baseline creatinine for 11,953 pts in a prospective registry (April 2000-September 2007)
• Pt stratification: pts with or without at least moderate CKD (creatinine clearance, <60 mL/min)
• Follow-up data obtained via linkage to a provincial registry

• Cox multiple-regression analysis identified independent predictors of late mortality and major adverse cardiac events (MACE) and examined association between DES use and late outcomes in presence/absence of CKD
• CKD present in 3070 pts (25.7%)
• In-hospital mortality and MACE significantly increased in CKD
• Survival and MACE-free survival reduced at 7 yrs
• CKD was an independent predictor of late mortality and MACE
• DES use was associated with a significant reduction in both
• In pts with CKD, DES use associated with reduced revascularization and reduced MACE but not reduced mortality

Today in Interventional...keeping you current

Receive free subspecialty "5-minute updates" via email

Effectiveness of Two-Year Clopidogrel + Aspirin in Abolishing the Risk of Very Late Thrombosis After Drug-Eluting Stent Implantation (from the TYCOON [Two-Year ClOpidOgrel Need] Study)
The American Journal of Cardiology, 11/05/09

Carotid artery stenting vs. endarterectomy
European Heart Journal, 10/30/09

Catheter Ablation of Supraventricular Arrhythmias and Atrial Fibrillation
American Family Physician, 11/12/09

See All of Interventional