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Capodanno D et al. – The SYNTAX score (SXscore) is a useful tool to predict cardiac mortality and major adverse cardiac events (MACE) in pts undergoing percutaneous revascularization of the left main coronary artery.

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Davide Capodanno, 07/02/09

This study validates the efficacy of SYNTAX score in predicting one-year clinical outcomes of patients undergoing left main PCI. The next challenge, however, is to understand if SYNTAX score effectively does what it was originally developed for, namely to be an aid in patient’s selection for the optimal revascularization treatment. For this purpose, a cut off of 34 has the potential to usefully distinguish patients at higher risk of cardiac death following PCI who may benefit most from surgery. Importantly, a number of potential drawbacks of SYNTAX score application emerged from this study: variables such as previous stenting or bypass grafting are not considered in the score algorithm; SYNTAX score calculation is not user-friendly, although some online tools are now available; finally, the parallel role of co-morbidities and clinical risk factors in predicting clinical outcomes of PCI patients remains an issue.

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