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Camici GG et al. – Rapamycin increases tissue factor (TF) activity and promotes arterial thrombosis in vivo at concentrations relevant in pts undergoing drug-eluting stents (DES) implantation; this effect may increase the thrombogenicity of DES. Since everolimus and zotarolimus augment endothelial TF expression and activity in vitro in a similar manner as rapamycin, these findings may also be relevant for second generation DES.

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