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See Latest ArticlesComparison of inflammatory response after implantation of sirolimus- and paclitaxel-eluting stents in porcine coronary arteries
Circulation, 07/02/09
Wilson GJ et al. – A high prevalence in a porcine model of diffuse granulomatous inflammation with sirolimus (CYPHER) stents, persisting at 180 days and associated with extensive artery remodeling, and persistent para-strut fibrin deposition with paclitaxel (TAXUS) stents emphasize the need for further sudy of biocompatibility with these and other novel combination drug/polymer drug-eluting stents.
Methods- Overlapping stents (CYPHER drug-eluting stents, Bx SONIC bare metal stents, TAXUS drug-eluting stents, Liberté bare metal stents) implanted in noninjured coronary arteries of 58 domestic swine
- Histopathologic study of proximal, overlapped, and distal stented segments
- Focus on inflammation at 30, 90, and 180 days
- Circumferential granulomatous inflammation in all stented segments defined as inflammation consisting of macrophages, multinucleated giant cells, lymphocytes, and granulocytes, including many eosinophils, adjacent to almost all struts
- Circumferential granulomatous inflammation more prevalent in CYPHER (9 of 23, 39%) vs TAXUS (1 of 21, 5%) and control bare metal stents (0 of 44) in combined 90- and 180-day cohorts
- Only CYPHER specimens showed marked adventitial inflammation and fibrosis with extensive remodeling
- Fibrin deposition within neointima and medial smooth muscle cell death greater in TAXUS vs CYPHER at 30 days, with more fibrin in TAXUS vs CYPHER through 90 days
Today in Basic Science/Genetics...keeping you current
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A selective endothelin-receptor antagonist to reduce blood pressure in patients with treatment-resistant hypertension: a randomised, double-blind, placebo-controlled trial
The Lancet, 10/27/09
Inflammatory mediators and premature coronary atherosclerosis in rheumatoid arthritis
Arthritis Care and Research , 11/03/09
Benefits and Difficulties in Measuring HDL Subfractions and Human Paraoxonase-1 Activity During Statin Treatment
Cardiovascular Drugs and Therapy, 11/03/09
Today in Inflammation...keeping you current
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Inflammatory mediators and premature coronary atherosclerosis in rheumatoid arthritis
Arthritis Care and Research , 11/03/09
Acute Decline in Renal Function, Inflammation, and Cardiovascular Risk after an Acute Coronary Syndrome
Clinical Journal of the American Society of Nephrology, 11/13/09
Arterial stiffness and cumulative inflammatory burden in rheumatoid arthritis: A dose-response relationship independent of established cardiovascular risk factors
Rheumatology, 10/28/09
Today in Interventional...keeping you current
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Effectiveness of Two-Year Clopidogrel + Aspirin in Abolishing the Risk of Very Late Thrombosis After Drug-Eluting Stent Implantation (from the TYCOON [Two-Year ClOpidOgrel Need] Study)
The American Journal of Cardiology, 11/05/09
Carotid artery stenting vs. endarterectomy
European Heart Journal, 10/30/09
Catheter Ablation of Supraventricular Arrhythmias and Atrial Fibrillation
American Family Physician, 11/12/09
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