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A cross-sectional survey of relationship between serum TSH level and blood pressure
Journal of Human Hypertension, 06/29/09

Liu D et al. – The prevalence of hypertension in subclinical hypothyroidism group was significantly higher than in euthyroid group in females. Change of thyroid-stimulating hormone (TSH) in normal range did not affect blood pressure.

• Study of the relationship between different levels of TSH and blood pressure in pts with subclinical hypothyroidism and euthyroidism
• Questionnaire survey for 1319 pts
• Measurements of blood pressure, height, and body weight
• Blood samples for serum TSH
• Assessment of FT3 and FT4 if abnormal TSH
• Pts classified as euthyroid group and subclinical hypothyroidism group
• Euthyroid group: group A (TSH 0.3–0.99 mIU l-1), group B (TSH 1.0–1.9 mIU l-1) and group C (TSH 1.91–4.8 mIU l-1)

• Different levels of serum TSH had no relation with systolic blood pressure (SBP) and diastolic blood pressure (DBP)
• Prevalence of hypertension in subclinical hypothyroidism group significantly higher than euthyroid group in females (41.3 vs 25.6%)
• Risk of hypertension in subclinical hypothyroidism group significantly higher than that in euthyroid group after adjusted for age, gender, smoking status, HOMA-IR (homoeostasis model assessment of insulin resistance) and body mass index
• Association stronger in females; no statistical significance in males
• Within normal range of TSH, both SBP and DBP similar among the 3 groups
• Prevalence and risk of hypertension also similar among the 3 groups

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