Cardiology Medical News about aggregated LDL;free cholesterol;local actin polymerization

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Aggregated LDL in contact with macrophages induces local increases in free cholesterol levels that regulate local actin polymerization
Arteriosclerosis, Thrombosis, and Vascular Biology, 06/29/09

Grosheva I et al. – Results describe a novel process during aggregated LDL (agLDL)–macrophage interactions in which local release of free cholesterol causes local actin polymerization, promoting a pathological positive feedback loop for increased catabolism of agLDL and eventual foam cell formation.

Methods

Study of whether engagement of agLDL by macrophages leads to local increases in free cholesterol levels and whether these increases in free cholesterol regulate signals that control cellular actin

Results

AgLDL resides for prolonged periods in surface-connected compartments
agLDL remains extracellular
An increase in free cholesterol occurs at sites of contact between agLDL and cells due to hydrolysis of agLDL-derived cholesteryl ester
Increased free cholesterol causes enhanced actin polymerization around agLDL
Inhibition of cholesteryl ester hydrolysis results in decreased actin polymerization

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