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See Latest ArticlesMyocardial microvascular function during acute coronary artery stenosis: Effect of hypertension and hypercholesterolaemia
Cardiovascular Research, 06/30/09
Zhu XY et al. – Findings show that early exposure to the cardiovascular risk factors high-cholesterol (HC) and renovascular hypertension (HTN) protects the heart from decreases in myocardial perfusion during acute subtotal acute subtotal coronary artery obstruction (CAO). This protective effect is associated with and potentially mediated by pre-emptive development of intra-myocardial microvessels that might serve as recruitable coronary collateral arteries (CCA).
Methods- Study of whether new microvessels that proliferate in early atherosclerosis are associated with myocardial protection during acute subtotal CAO
- Induction of acute left anterior descending CAO by a balloon catheter in pigs after 12 wks of HC diet, HTN, or normal controls
- Electron beam computed tomography (CT) to assess in vivo cardiac structure, myocardial perfusion, and functional response to IV adenosine and CAO
- Micro-CT to assess ex vivo intra-myocardial microvessels
- Immunoblotting for myocardial expression of growth factors
- Basal myocardial perfusion and microvascular permeability similar among groups
- Responses to adenosine attenuated in HC and HTN
- Significant decline in myocardial perfusion in normal pigs during acute CAO attenuated in HC and abolished in HTN
- CAO elicited increase in normal anterior wall microvascular permeability, attenuated in HC and HTN
- Microvascular spatial density significantly elevated in HC and HTN, with increased myocardial growth factor expression
Today in Atherosclerosis/Lipids...keeping you current
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The American Journal of Cardiology, 10/21/09
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Today in Coronary Artery Disease...keeping you current
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Acute Coronary Syndromes: Diagnosis and Management, Part I
Mayo Clinic Proceedings, 10/05/09
Acute medical management of the non-ST-segment elevation acute coronary syndromes (NSTE-ACS) in older patients
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Prognostic value of peak and post-exercise treadmill exercise echocardiography in patients with known or suspected coronary artery disease
European Heart Journal, 10/16/09
Today in Hypertension...keeping you current
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A selective endothelin-receptor antagonist to reduce blood pressure in patients with treatment-resistant hypertension: a randomised, double-blind, placebo-controlled trial
The Lancet, 10/27/09
Obesity-Related Cardiorenal Syndrome
The Journal of Clinical Hypertension, 10/20/09
Pravastatin and cardiovascular risk in moderate chronic kidney disease
Atherosclerosis, 10/07/09
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