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Delayed neutrophil apoptosis in patients with unstable angina: relation to C-reactive protein and recurrence of instability
European Heart Journal, 06/30/09

Biasucci LM et al. – Findings show delayed polymorphonuclear neutrophils (PMNs) apoptosis in unstable angina (UA). This alteration may be involved in persistence of inflammatory activation and affects recurrence of instability.

• Study of spontaneous PMNs apoptosis in UA and its association with recurrence of instability
• Compared PMNs apoptotic rate at 4 hr and 24 hr in pts with UA, stable angina (SA), and controls (H) with 2 different protocols by flow cytometry
• Measurement of apoptotic rate of isolated PMNs (Protocol 1) in 30 UA pts, 13 SA pts, and 34 H; and apoptosis of PMNs in whole blood culture (Protocol 2) in further 10 UA pts, 7 SA pts, and 6 H
• Measurement of serum high-sensitivity C-reactive protein

• Decreased apoptotic rate for PMNs of UA pts vs with SA pts and H at 4 hr in Protocol 1 and at 24 hr in Protocol 2
• In overall population, negative correlation between apoptotic rate at 4 hr and high-sensitivity C-reactive protein levels
• Among 40 pts with UA, 6 had early recurrence of symptoms
• For pts with early recurrence of symptoms apoptotic rate significantly reduced vs UA pts without recurrence of symptoms

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