Cardiology Medical News about acute coronary syndromes;enhanced expression of hemoglobin

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Enhanced expression of haemoglobin scavenger receptor in accumulated macrophages of culprit lesions in acute coronary syndromes
European Heart Journal, 06/30/09

Yunoki K et al. – Findings suggest a positive association among intra-plaque hemorrhage, enhanced expression of Hb scavenger receptor, and lipid peroxidation in human unstable plaques.

Methods

Immunohistochemical study of relationship between intra-plaque hemorrhage, 4-HNE (4-hydroxy-2-nonenal), an index of lipid peroxidation, and the Hb scavenger receptor (CD163)
Use of coronary atherectomy specimens from 74 pts with stable angina pectoris (39 SAP) or unstable angina pectoris (35 UAP)
Atherectomy samples stained with antibodies against glycophorin A (a protein specific to erythrocyte membranes), CD31, 4-HNE, and CD163

Results

On quantitative analysis, glycophorin A-positive areas, 4-HNE-positive macrophage score, and CD163-positive macrophage score in UAP pts significantly higher than in SAP pts
Percentage of glycophorin A-positive area showed significant positive correlation with number of CD31-positive microvessels and 4-HNE-positive macrophage score
CD163-positive macrophage score positively correlated with glycophorin A-positive area and the 4-HNE-positive macrophage score

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