Your Article Summary
See Latest ArticlesEnhanced expression of haemoglobin scavenger receptor in accumulated macrophages of culprit lesions in acute coronary syndromes
European Heart Journal, 06/30/09
Yunoki K et al. – Findings suggest a positive association among intra-plaque hemorrhage, enhanced expression of Hb scavenger receptor, and lipid peroxidation in human unstable plaques.
Methods- Immunohistochemical study of relationship between intra-plaque hemorrhage, 4-HNE (4-hydroxy-2-nonenal), an index of lipid peroxidation, and the Hb scavenger receptor (CD163)
- Use of coronary atherectomy specimens from 74 pts with stable angina pectoris (39 SAP) or unstable angina pectoris (35 UAP)
- Atherectomy samples stained with antibodies against glycophorin A (a protein specific to erythrocyte membranes), CD31, 4-HNE, and CD163
- On quantitative analysis, glycophorin A-positive areas, 4-HNE-positive macrophage score, and CD163-positive macrophage score in UAP pts significantly higher than in SAP pts
- Percentage of glycophorin A-positive area showed significant positive correlation with number of CD31-positive microvessels and 4-HNE-positive macrophage score
- CD163-positive macrophage score positively correlated with glycophorin A-positive area and the 4-HNE-positive macrophage score
Related Articles
Acute Coronary Syndromes: Diagnosis and Management, Part II
Mayo Clinic Proceedings, 11/03/09
Relevance Score: 83%
Activated factor XII type A and B-type natriuretic peptide are complementary and incremental predictors of mortality in patients following admission with acute coronary syndrome
Blood Coagulation & Fibrinolysis, 11/03/09
Relevance Score: 83%
Endogenous tissue plasminogen activator and risk of recurrent cardiac events after an acute coronary syndrome in the MIRACL study
Atherosclerosis, 10/13/09
Relevance Score: 83%
Effects of Nordic Walking training on exercise capacity and fitness in men participating in early, short-term inpatient cardiac rehabilitation after an acute coronary syndrome — a controlled trial
Clinical Rehabilitation, 11/12/09
Relevance Score: 82%
Management of acute coronary syndrome in a case of Behcets disease
Blood Coagulation & Fibrinolysis, 11/03/09
Relevance Score: 82%
Today in Basic Science/Genetics...keeping you current
Receive free subspecialty "5-minute updates" via email
WNK kinases and blood pressure control
Current Hypertension Reports, 12/14/09
Insights into the Pathogenesis and Genetic Background of Patency of the Ductus Arteriosus
Neonatology, 12/09/09
Context Dependent Associations between Variation in Risk of Ischemic Heart Disease and Variation in the 5' Promoter Region of the Apolipoprotein E Gene in Danish Females
Circulation: Cardiovascular Genetics, 12/08/09
Today in Coronary Artery Disease...keeping you current
Receive free subspecialty "5-minute updates" via email
Has the frequency of bleeding changed over time for patients presenting with an acute coronary syndrome? The Global Registry of Acute Coronary Events
European Heart Journal, 12/14/09
Relationship between LDL, HDL, blood pressure and atheroma progression in the coronaries
Current Opinion in Lipidology, 12/14/09
Personalized antiplatelet therapy for coronary artery disease patients: is this the future?
Expert Review of Cardiovascular Therapy , 12/14/09