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Statins and prevention of atrial fibrillation in patients with heart failure
International Journal of Cardiology, 06/26/09

Liu T et al. – A review of statins and prevention of atrial fibrillation (AF) in heart failure (HF) pts summarizes recent efficacy and outcome data as well as the anti-arrhythmic mechanisms of statin in this setting.

Methods

Review of statins and prevention of AF in HF

Results

Statins are highly effective and widely used lipid-lowering agents in clinical practice with pleiotropic properties beyond cholesterol lowering
Trials show reduced cardiovascular morbidity and mortality in both primary and secondary prevention with statins
Statins may have beneficial effects on cardiovascular outcomes in HF, specifically in prevention of AF
Anti-arrhythmic mechanisms of statins regarding AF prevention in HF patients are not fully understood
Mechanisms may be related to pleiotropic effects: anti-inflammatory, antioxidant, atrial remodeling attenuation, ion channel stabilization, and autonomic nervous system regulation

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