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Increased muscle sympathetic nerve activity predicts mortality in heart failure patients
International Journal of Cardiology, 06/26/09

Barretto ACP et al. – Muscle sympathetic nerve activity (MSNA) and forearm blood flow predict mortality rate in heart failure (HF) pts. Whether therapies that specifically target these abnormalities can improve survival in heart failure is pending further study.

Methods

Study of whether MSNA and forearm blood flow predict mortality in chronic heart failure pts
Assessment of 122 heart failure pts, NYHA II–IV, age 50±1 yrs, LVEF 33±1%, and LVDD 7.1±0.2 mm, followed for 1 yr
MSNA directly measured from peroneal nerve by microneurography
Forearm blood flow by venous occlusion plethysmography

Results

After 1 yr, cardiac death in 34 pts
On univariate analysis MSNA, forearm blood flow, LVDD, LVEF, and heart rate were significant predictors of mortality
On multivariate analysis, only MSNA and forearm blood flow were significant independent predictors of mortality
Baed on median levels of MSNA, survival rate significantly lower in pts with >49 bursts/min
Survival rate significantly lower in pts with forearm blood flow <1.87 ml/min/100 mL

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