Cardiology Medical News about implanted cardioverter defibrillator devices;ventricular fibrillation frequency

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Ventricular fibrillation frequency from implanted cardioverter defibrillator devices
Europace, 06/25/09

Panfilov I et al. – The dominant frequency (DF) of short intervals of induced ventricular fibrillation (VF) is highly reproducible and is sensitive to pharmacologic interventions that extend effective refractory period. Such estimates of DF may thus have clinical utility and in pts with implanted cardioverter defibrillator devices (ICDs) provide a means of investigating mechanisms underlying the initiation and early phases of VF.

Methods

Study of the reproducibility of the DF during separate VF events on stored electrograms (EGMs) from ICDs
Assessment of 82 pts with a Medtronic ICD who had 2 induced VF episodes during ICD testing
Extraction of EGMs recorded during both episodes
Determination of DF using fast Fourier transform

Results

Mean DF for population: 4.7 ± 0.6 Hz, corresponding to 213-ms cycle length
First and second VF episodes highly correlated, showing highly reproducible DF
DF significantly lower for 18 pts on Class III agents vs remaining 63
DF of ischemic heart disease pts did not differ from that of dilated cardiomyopathy pts

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