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The vascular risk associations with migraine: Relation to migraine susceptibility and progression
Atherosclerosis, 06/29/09

Hamed SA et al. – A review of the vascular risk associations with migraine summarizes the relationship to migraine susceptibility and progression. Understanding of migraine as a risk for vascular diseases raises important clinical implications, recommendations, and future perspectives in migraine treatment and prevention.

• Review of vascular risk associations with migraine

• Changes in cortical excitability, neuroinflammation and dysfunction of the vascular wall contribute to migraine pathophysiology
• Prolonged repeat migraine result in inflammatory arteriopathy of cranial vessels
• Migraine may be associated with special pattern of inflammatory markers and some adverse vascular risk factors
• Risk factors: increased levels of CRP, ILs, TNF-alpha and adhesion molecules
• Factors serve as markers of systemic inflammation, oxidative stress and thrombosis, increased body weight, high blood pressure, hypercholesterolemia, impaired insulin sensitivity, high homocysteine levels, stroke, and coronary heart disease

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