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Heit JA et al. – Diabetes mellitus and diabetes complications are not independent risk factors for incident venous thromboembolism (VTE).

Methods

Study of an independent association for diabetes with incident VTE
Use of Rochester Epidemiology Project resources
Identification of all Olmsted County, MN residents who met objective criteria for incident VTE over 25-yr period, 1976-2000 (n=1922), and 1-2 resident controls/case (n=2115)
Controls matched on age, gender, and length of medical historyReview of complete medical histories in community for previously identified independent VTE risk factors and diabetes-related variables
Test of diabetes and diabetes complications as potential VTE risk factors, both alone and after adjusting for VTE risk factors
Diabetes complications studied: retinopathy, nephropathy or neuropathy, and ketoacidosis
Diabetes defined by clinical diagnosis or by stricter criteria: fasting ambulatory blood glucose ≥140 mg/dL or antidiabetic drug therapy

Results

On univariate analysis, diabetes by clinical diagnosis or by stricter criteria and diabetes complications, were associated with overall incident VTE
After controlling for hospitalization for major surgery or medical illness and nursing home confinement, diabetes was no longer associated with VTE

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